The operate of SIK1 in tumorigenesis. SIK1 is a tumor suppressor gene, which performs a vital regulatory part in GNAS, KRAS mutation and LKB1 deletion mediated tumors. SIK1 inhibits CREB mediated transcription and impacts cancer cell proliferation, metabolic reprogramming and inflammatory microenvironment. SIK1 could also advertise most cancers cel